Women's Reproductive Sciences Research: Nelson Lab
Moley Lab, Washington University School of Medicine
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Placental Trophoblast Apoptosis

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For many years, the Nelson lab has studied stress-induced apoptosis in trophoblasts. We have found that stress-induced apoptosis occurs readily in cytotrophoblasts, and that cytotrophoblast apoptosis is significantly increased in pregnancies complicated by IUGR and/or preeclampsia.

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Placental Trophoblast Autophagy

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We recently made the novel finding that autophagy is induced by stress in cytotrophoblasts. Notably, autophagy in these stressed cytotrophoblasts serves a major pro-survival role, and serves to reduce the levels of cell death due to apoptosis.

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Pomegrante Juice as Antenatal Therapy

Pomegrante Juice as Antenatal Therapy

Pomegranate juice is full of polyphenols, which are biologically active compounds. Studies from other labs have indicated pomegranate juice can reduce the deleterious effects of excess reactive oxygen species in cardiovascular systems.

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About Us

Dr. Nelson’s research focuses on developing a better understanding of the human placenta with a goal of improving maternal and fetal outcomes during and after pregnancy. Preeclampsia, intrauterine growth restriction (IUGR), or both, complicate ~7.5% of all pregnancies and these maladies are often associated with increased placental stress and placental dysfunction. Placental dysfunction is a major cause of perinatal morbidity and mortality and can have life-long negative effects on both mother and child.

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